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Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo
Scd6 protein family members are evolutionarily conserved components of translationally silent mRNA granules. Yeast Scd6 interacts with Dcp2 and Dhh1, respectively a subunit and a regulator of the mRNA decapping enzyme, and also associates with translation initiation factor eIF4G to inhibit translati...
Autores principales: | Zeidan, Quira, He, Feng, Zhang, Fan, Zhang, Hongen, Jacobson, Allan, Hinnebusch, Alan G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307823/ https://www.ncbi.nlm.nih.gov/pubmed/30532217 http://dx.doi.org/10.1371/journal.pgen.1007806 |
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