Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study

The RNA recognition motif (RRM) is the most common RNA binding domain across eukaryotic proteins. It is therefore of great value to engineer its specificity to target RNAs of arbitrary sequence. This was recently achieved for the RRM in Rbfox protein, where four mutations R118D, E147R, N151S, and E1...

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Detalles Bibliográficos
Autores principales: Bochicchio, Anna, Krepl, Miroslav, Yang, Fan, Varani, Gabriele, Sponer, Jiri, Carloni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307825/
https://www.ncbi.nlm.nih.gov/pubmed/30521520
http://dx.doi.org/10.1371/journal.pcbi.1006642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307825/
https://www.ncbi.nlm.nih.gov/pubmed/30521520
http://dx.doi.org/10.1371/journal.pcbi.1006642

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