Bexarotene – a novel modulator of AURKA and the primary cilium in VHL-deficient cells

Loss of the gene von Hippel–Lindau (VHL) is associated with loss of primary cilia and is causally linked to elevated levels of Aurora kinase A (AURKA). We developed an image-based high-throughput screening (HTS) assay using a dual-labeling image analysis strategy that identifies both the cilium and...

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Detalles Bibliográficos
Autores principales: Chowdhury, Pratim, Powell, Reid T., Stephan, Clifford, Uray, Ivan P., Talley, Tia, Karki, Menuka, Tripathi, Durga Nand, Park, Yong Sung, Mancini, Michael A., Davies, Peter, Dere, Ruhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307881/
https://www.ncbi.nlm.nih.gov/pubmed/30518623
http://dx.doi.org/10.1242/jcs.219923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307881/
https://www.ncbi.nlm.nih.gov/pubmed/30518623
http://dx.doi.org/10.1242/jcs.219923

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