Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease

Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The excessive activity of AChE causes various neuronal problems, particularly dementia and neuronal cell deaths. Generally, anti-AChE drugs induce some serious neuronal side effects in humans. Therefore, this study...

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Detalles Bibliográficos
Autores principales: Vijayakumar, Subramaniyan, Manogar, Palani, Prabhu, Srinivasan, Sanjeevkumar Singh, Ram Avadhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308024/
https://www.ncbi.nlm.nih.gov/pubmed/30595949
http://dx.doi.org/10.1016/j.jpha.2017.07.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308024/
https://www.ncbi.nlm.nih.gov/pubmed/30595949
http://dx.doi.org/10.1016/j.jpha.2017.07.006

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