Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells

AU‐rich elements (ARE) exist in the 3′‐untranslated regions of the mRNA transcribed from cell growth‐related genes such as proto‐oncogenes, cyclin‐related genes, and growth factors. HuR binds and stabilizes ARE‐mRNA. HuR is expressed abundantly in cancer cells and related malignant phenotypes. HuR k...

Descripción completa

Detalles Bibliográficos
Autores principales: Kakuguchi, Wataru, Nomura, Takao, Kitamura, Tetsuya, Otsuguro, Satoko, Matsushita, Kazuhiro, Sakaitani, Masahiro, Maenaka, Katsumi, Tei, Kanchu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308099/
https://www.ncbi.nlm.nih.gov/pubmed/30449075
http://dx.doi.org/10.1002/cam4.1877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308099/
https://www.ncbi.nlm.nih.gov/pubmed/30449075
http://dx.doi.org/10.1002/cam4.1877

Ejemplares similares