EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK‐eIF2α‐GRP94 and IRE1α‐XBP1‐GRP78

The activation of epidermal growth factor receptor (EGFR) is associated with radioresistance in malignant tumors. Specifically, radiation can destroy endoplasmic reticulum (ER) homeostasis to induce ER stress (ERS). However, the effect of EGFR‐mediated regulation of ERS signaling pathway on radiosen...

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Detalles Bibliográficos
Autores principales: Zhang, Miao, Han, Ning, Jiang, Yuanjun, Wang, Jie, Li, Gaiyan, Lv, Xintong, Li, Guang, Qiao, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308109/
https://www.ncbi.nlm.nih.gov/pubmed/30414263
http://dx.doi.org/10.1002/cam4.1862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308109/
https://www.ncbi.nlm.nih.gov/pubmed/30414263
http://dx.doi.org/10.1002/cam4.1862

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