Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two distinct ECD sites, which reorientates the N-terminal LDLa module to act...

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Detalles Bibliográficos
Autores principales: Hoare, Bradley L., Bruell, Shoni, Sethi, Ashish, Gooley, Paul R., Lew, Michael J., Hossain, Mohammed A., Inoue, Asuka, Scott, Daniel J., Bathgate, Ross A.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309025/
https://www.ncbi.nlm.nih.gov/pubmed/30594862
http://dx.doi.org/10.1016/j.isci.2018.12.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309025/
https://www.ncbi.nlm.nih.gov/pubmed/30594862
http://dx.doi.org/10.1016/j.isci.2018.12.004

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