Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model

BACKGROUND: Neuron-microglia communication plays a crucial role in the motor neurons (MNs) death in amyotrophic lateral sclerosis (ALS). Neurons can express chemokine (C-X3-C motif) ligand 1 (CX3CL1), which mediates microglial activation via interacting with its sole receptor CX3CR1 in microglia. In...

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Detalles Bibliográficos
Autores principales: Zhang, Jingjing, Liu, Yufei, Liu, Xinyao, Li, Song, Cheng, Cheng, Chen, Sheng, Le, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309063/
https://www.ncbi.nlm.nih.gov/pubmed/30607245
http://dx.doi.org/10.1186/s40035-018-0138-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309063/
https://www.ncbi.nlm.nih.gov/pubmed/30607245
http://dx.doi.org/10.1186/s40035-018-0138-4

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