Evolution of cation binding in the active sites of P-loop nucleoside triphosphatases in relation to the basic catalytic mechanism

The ubiquitous P-loop fold nucleoside triphosphatases (NTPases) are typically activated by an arginine or lysine ‘finger’. Some of the apparently ancestral NTPases are, instead, activated by potassium ions. To clarify the activation mechanism, we combined comparative structure analysis with molecula...

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Detalles Bibliográficos
Autores principales: Shalaeva, Daria N, Cherepanov, Dmitry A, Galperin, Michael Y, Golovin, Andrey V, Mulkidjanian, Armen Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310460/
https://www.ncbi.nlm.nih.gov/pubmed/30526846
http://dx.doi.org/10.7554/eLife.37373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310460/
https://www.ncbi.nlm.nih.gov/pubmed/30526846
http://dx.doi.org/10.7554/eLife.37373

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