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Complete clinical and functional recovery following low-dose methotrexate related paraparesis in a patient with compound c.1298A>C AND c.677C>T MTHFR polymorphism: A case report
RATIONALE: The mechanisms of action of MTX (methotrexate) in the treatment of RA (rheumatoid arthritis) and PsA (psoriatic arthritis) is related to its antifolic activity, due to the high affinity for enzymes that require folate cofactors as dihydrofolate reductase and to the anti-inflammatory activ...
Autores principales: | Saviola, Gianantonio, Abdi-Ali, Lul, Sacco, Silvano, Comini, Laura, Plewnia, Katrin, Rossi, Maja, Orrico, Alfredo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310541/ https://www.ncbi.nlm.nih.gov/pubmed/30544400 http://dx.doi.org/10.1097/MD.0000000000013350 |
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