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Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

The emergence of primordial RNA-based life would have required the abiotic synthesis of nucleotides, and their participation in nonenzymatic RNA replication. Although considerable progress has been made toward potentially prebiotic syntheses of the pyrimidine nucleotides (C and U) and their 2-thio v...

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Detalles Bibliográficos
Autores principales: Kim, Seohyun Chris, O’Flaherty, Derek K., Zhou, Lijun, Lelyveld, Victor S., Szostak, Jack W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310819/
https://www.ncbi.nlm.nih.gov/pubmed/30509978
http://dx.doi.org/10.1073/pnas.1814367115