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Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA
The emergence of primordial RNA-based life would have required the abiotic synthesis of nucleotides, and their participation in nonenzymatic RNA replication. Although considerable progress has been made toward potentially prebiotic syntheses of the pyrimidine nucleotides (C and U) and their 2-thio v...
Autores principales: | Kim, Seohyun Chris, O’Flaherty, Derek K., Zhou, Lijun, Lelyveld, Victor S., Szostak, Jack W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310819/ https://www.ncbi.nlm.nih.gov/pubmed/30509978 http://dx.doi.org/10.1073/pnas.1814367115 |
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