A Strategy to Refine the Phenotyping Approach and Its Implementation to Predict Drug Clearance: A Physiologically Based Pharmacokinetic Simulation Study

The phenotyping approach to predict drug metabolism activity is often hampered by a lack of correlation between the probe and the drug of interest. In this article, we present a strategy to refine the phenotyping approach based on a physiologically based pharmacokinetic simulation (implemented in Si...

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Detalles Bibliográficos
Autores principales: Adiwidjaja, Jeffry, Boddy, Alan V., McLachlan, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310868/
https://www.ncbi.nlm.nih.gov/pubmed/30260092
http://dx.doi.org/10.1002/psp4.12355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310868/
https://www.ncbi.nlm.nih.gov/pubmed/30260092
http://dx.doi.org/10.1002/psp4.12355

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