A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug‐Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide

Evofosfamide is a cytotoxic small‐molecule prodrug preferentially activated under hypoxic conditions. The cytotoxicity of evofosfamide impacted the generation of in vitro drug‐drug interaction (DDI) data, especially in vitro induction results. Therefore, a novel physiologically based pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Lüpfert, Christian, Dyroff, Martin, von Richter, Oliver, Gallemann, Dieter, El Bawab, Samer, Dolgos, Hugues, Jung, Don, Hecht, Stefan, Johne, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310869/
https://www.ncbi.nlm.nih.gov/pubmed/30311747
http://dx.doi.org/10.1002/psp4.12360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310869/
https://www.ncbi.nlm.nih.gov/pubmed/30311747
http://dx.doi.org/10.1002/psp4.12360

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