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A Systematic Evaluation of Effect of Adherence Patterns on the Sample Size and Power of a Clinical Study
The objective of our study was to evaluate the effect of adherence patterns on the sample size and power of a clinical trial. Simulations from a population pharmacokinetic/pharmacodynamic (PK/PD) model linked to an adherence model were used. Four types of drug characteristics, such as long (~35 hour...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310871/ https://www.ncbi.nlm.nih.gov/pubmed/30291680 http://dx.doi.org/10.1002/psp4.12361 |