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A Systematic Evaluation of Effect of Adherence Patterns on the Sample Size and Power of a Clinical Study

The objective of our study was to evaluate the effect of adherence patterns on the sample size and power of a clinical trial. Simulations from a population pharmacokinetic/pharmacodynamic (PK/PD) model linked to an adherence model were used. Four types of drug characteristics, such as long (~35 hour...

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Detalles Bibliográficos
Autores principales:	Mallayasamy, Surulivelrajan, Chaturvedula, Ayyappa, Blaschke, Terrence, Fossler, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310871/ https://www.ncbi.nlm.nih.gov/pubmed/30291680 http://dx.doi.org/10.1002/psp4.12361

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