Comparison of the efficacy and safety of tocilizumab for colchicine-resistant or colchicine-intolerant familial Mediterranean fever: study protocol for an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial

BACKGROUND: Familial Mediterranean fever (FMF) is an inherited disorder caused by a number of mutations of the Mediterranean fever (MEFV) gene, coding a protein named pyrin that acts as a major regulatory component of the inflammasome. The first-line drug for FMF treatment is colchicine, but 10% of...

Descripción completa

Detalles Bibliográficos
Autores principales: Koga, Tomohiro, Sato, Shuntaro, Miyamoto, Junya, Hagimori, Naoko, Kawazoe, Yurika, Arinaga, Kumiko, Fukushima, Chizu, Yamamoto, Hiroshi, Kawakami, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311086/
https://www.ncbi.nlm.nih.gov/pubmed/30594222
http://dx.doi.org/10.1186/s13063-018-3105-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311086/
https://www.ncbi.nlm.nih.gov/pubmed/30594222
http://dx.doi.org/10.1186/s13063-018-3105-6

Ejemplares similares