Genomic characterization of the RH locus detects complex and novel structural variation in multi-ethnic cohorts

PURPOSE: Rh antigens can provoke severe alloimmune reactions, particularly in high-risk transfusion contexts such as, sickle cell disease. Rh antigens are encoded by the paralogs, RHD and RHCE, located in one of the most complex genetic loci. Our goal was to characterize RH genetic variation in mult...

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Detalles Bibliográficos
Autores principales: Wheeler, Marsha M., Lannert, Kerry W., Huston, Haley, Fletcher, Shelley N., Harris, Samantha, Teramura, Gayle, Maki, Helena J., Frazar, Chris, Underwood, Jason G., Shaffer, Tristan, Correa, Adolfo, Delaney, Meghan, Reiner, Alex P., Wilson, James G., Nickerson, Deborah A., Johnsen, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311147/
https://www.ncbi.nlm.nih.gov/pubmed/29955105
http://dx.doi.org/10.1038/s41436-018-0074-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311147/
https://www.ncbi.nlm.nih.gov/pubmed/29955105
http://dx.doi.org/10.1038/s41436-018-0074-9

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