Accurate Estimation of Ligand Binding Affinity Changes upon Protein Mutation

[Image: see text] The design of proteins with novel ligand-binding functions holds great potential for application in biomedicine and biotechnology. However, our ability to engineer ligand-binding proteins is still limited, and current approaches rely primarily on experimentation. Computation could...

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Detalles Bibliográficos
Autores principales: Aldeghi, Matteo, Gapsys, Vytautas, de Groot, Bert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311686/
https://www.ncbi.nlm.nih.gov/pubmed/30648154
http://dx.doi.org/10.1021/acscentsci.8b00717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311686/
https://www.ncbi.nlm.nih.gov/pubmed/30648154
http://dx.doi.org/10.1021/acscentsci.8b00717

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