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Accurate Estimation of Ligand Binding Affinity Changes upon Protein Mutation
[Image: see text] The design of proteins with novel ligand-binding functions holds great potential for application in biomedicine and biotechnology. However, our ability to engineer ligand-binding proteins is still limited, and current approaches rely primarily on experimentation. Computation could...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311686/ https://www.ncbi.nlm.nih.gov/pubmed/30648154 http://dx.doi.org/10.1021/acscentsci.8b00717 |