Cargando…
Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities
BACKGROUND: Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases remains not well established, and few studies have confirmed their molecular predi...
Autores principales: | Li, Haiquan, Fan, Jungwei, Vitali, Francesca, Berghout, Joanne, Aberasturi, Dillon, Li, Jianrong, Wilson, Liam, Chiu, Wesley, Pumarejo, Minsu, Han, Jiali, Kenost, Colleen, Koripella, Pradeep C., Pouladi, Nima, Billheimer, Dean, Bedrick, Edward J., Lussier, Yves A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311938/ https://www.ncbi.nlm.nih.gov/pubmed/30598089 http://dx.doi.org/10.1186/s12920-018-0428-9 |
Ejemplares similares
-
‘Single-subject studies’-derived analyses unveil altered biomechanisms between very small cohorts: implications for rare diseases
por: Aberasturi, Dillon, et al.
Publicado: (2021) -
Precision drug repurposing via convergent eQTL-based molecules and pathway targeting independent disease-associated polymorphisms
por: Vitali, Francesca, et al.
Publicado: (2019) -
Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions
por: Li, Haiquan, et al.
Publicado: (2016) -
Single subject transcriptome analysis to identify functionally signed gene set or pathway activity
por: Berghout, Joanne, et al.
Publicado: (2018) -
A Single-Subject Method to Detect Pathways Enriched With Alternatively Spliced Genes
por: Schissler, Alfred Grant, et al.
Publicado: (2019)