2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia

Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia. 2-Bromopalmitate, a palmitate analogue, was initially identified as an inhibitor of fatty acid oxi...

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Detalles Bibliográficos
Autores principales: Lu, Ying, Yan, Jin-Song, Xia, Li, Qin, Kang, Yin, Qian-Qian, Xu, Hong-Tao, Gao, Meng-Qing, Qu, Xiao-Ning, Sun, Yu-Ting, Chen, Guo-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312026/
https://www.ncbi.nlm.nih.gov/pubmed/30076181
http://dx.doi.org/10.3324/haematol.2018.191916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312026/
https://www.ncbi.nlm.nih.gov/pubmed/30076181
http://dx.doi.org/10.3324/haematol.2018.191916

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