The allogeneic HLA-DP-restricted T-cell repertoire provoked by allogeneic dendritic cells contains T cells that show restricted recognition of hematopoietic cells including primary malignant cells

Stem cell grafts from 10/10 HLA-matched unrelated donors are often mismatched for HLA-DP. In some patients, donor T-cell responses targeting the mismatched HLA-DP allele(s) have been found to induce a specific graft-versus-leukemia effect without coinciding graft-versus-host disease, whereas in othe...

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Detalles Bibliográficos
Autores principales: Laghmouchi, Aicha, Hoogstraten, Conny, van Balen, Peter, Falkenburg, J.H. Frederik, Jedema, Inge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312030/
https://www.ncbi.nlm.nih.gov/pubmed/30237261
http://dx.doi.org/10.3324/haematol.2018.193680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312030/
https://www.ncbi.nlm.nih.gov/pubmed/30237261
http://dx.doi.org/10.3324/haematol.2018.193680

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