Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice

Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of pulmonary fibrosis. Nintedanib, a multi-kinase inhibitor that targets several tyrosine kinases, including PDGF receptor (PDGFR), was recently approved as an anti-fibrotic agent to reduce the deterioration of FVC in pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Kishi, Masami, Aono, Yoshinori, Sato, Seidai, Koyama, Kazuya, Azuma, Momoyo, Abe, Shuichi, Kawano, Hiroshi, Kishi, Jun, Toyoda, Yuko, Okazaki, Hiroyasu, Ogawa, Hirohisa, Uehara, Hisanori, Nishioka, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312310/
https://www.ncbi.nlm.nih.gov/pubmed/30596712
http://dx.doi.org/10.1371/journal.pone.0209786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312310/
https://www.ncbi.nlm.nih.gov/pubmed/30596712
http://dx.doi.org/10.1371/journal.pone.0209786

Ejemplares similares