Cargando…

Quantitative RNAseq analysis of Ugandan KS tumors reveals KSHV gene expression dominated by transcription from the LTd downstream latency promoter

KSHV is endemic in Uganda and the HIV epidemic has dramatically increased the incidence of Kaposi sarcoma (KS). To investigate the role of KSHV in the development of KS, we obtained KS biopsies from ART-naïve, HIV-positive individuals in Uganda and analyzed the tumors using RNAseq to globally charac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rose, Timothy M., Bruce, A. Gregory, Barcy, Serge, Fitzgibbon, Matt, Matsumoto, Lisa R., Ikoma, Minako, Casper, Corey, Orem, Jackson, Phipps, Warren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312348/ https://www.ncbi.nlm.nih.gov/pubmed/30557332 http://dx.doi.org/10.1371/journal.ppat.1007441

Ejemplares similares

KSHV oral shedding and plasma viremia result in significant changes in the extracellular tumorigenic miRNA expression profile in individuals infected with the malaria parasite
por: Ikoma, Minako, et al.
Publicado: (2018)

Experimental co-transmission of Simian Immunodeficiency Virus (SIV) and the macaque homologs of the Kaposi Sarcoma-Associated Herpesvirus (KSHV) and Epstein-Barr Virus (EBV)
por: Bruce, A. Gregory, et al.
Publicado: (2018)

KSHV LANA—The Master Regulator of KSHV Latency
por: Uppal, Timsy, et al.
Publicado: (2014)

Regulation of KSHV Latency and Lytic Reactivation
por: Broussard, Grant, et al.
Publicado: (2020)

Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children
por: Gantt, Soren, et al.
Publicado: (2010)

Macrophages drive KSHV B cell latency
por: Szymula, Agnieszka, et al.
Publicado: (2023)

Latently KSHV-Infected Cells Promote Further Establishment of Latency upon Superinfection with KSHV
por: Gam ze Letova, Chen, et al.
Publicado: (2021)

The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients
Publicado: (1996)

Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells
por: Bruce, A. Gregory, et al.
Publicado: (2017)

Identifying predictors of increased quantities of human Herpesvirus 8 DNA detection at oropharyngeal and plasma sites among Ugandan adults with and without HIV and Kaposi Sarcoma
por: Phipps, Warren, et al.
Publicado: (2012)

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice
por: Sin, Sang-Hoon, et al.
Publicado: (2015)

MLL1 is regulated by KSHV LANA and is important for virus latency
por: Tan, Min, et al.
Publicado: (2021)

Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women
por: Wakeham, Katie, et al.
Publicado: (2011)

Higher Levels of Neutralizing Antibodies against KSHV in KS Patients Compared to Asymptomatic Individuals from Zambia
por: Kumar, Pankaj, et al.
Publicado: (2013)

Virus and host-specific differences in oral human herpesvirus shedding kinetics among Ugandan women and children
por: Matrajt, Laura, et al.
Publicado: (2017)

Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency
por: Sarek, Grzegorz, et al.
Publicado: (2010)

Macaque Homologs of EBV and KSHV Show Uniquely Different Associations with Simian AIDS-related Lymphomas
por: Bruce, A. Gregory, et al.
Publicado: (2012)

Influence of ND10 Components on Epigenetic Determinants of Early KSHV Latency Establishment
por: Günther, Thomas, et al.
Publicado: (2014)

BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency
por: Chen, Horng-Shen, et al.
Publicado: (2017)

Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency
por: Zhang, Huirong, et al.
Publicado: (2022)

Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation
por: Gantt, Soren, et al.
Publicado: (2015)

KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA
por: Cheng, Fang, et al.
Publicado: (2009)

Sphingosine Kinase-2 Maintains Viral Latency and Survival for KSHV-Infected Endothelial Cells
por: Dai, Lu, et al.
Publicado: (2014)

A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency
por: Cai, Qiliang, et al.
Publicado: (2013)

Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage
por: De Leo, Alessandra, et al.
Publicado: (2017)

Increased frequency and quantity of mucosal and plasma cytomegalovirus replication among Ugandan Adults Living with HIV
por: McClymont, Elisabeth, et al.
Publicado: (2023)

Androgen receptor transactivates KSHV noncoding RNA PAN to promote lytic replication–mediated oncogenesis: A mechanism of sex disparity in KS
por: Ding, Mingzhu, et al.
Publicado: (2021)

Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1
por: Kumar, Shivani, et al.
Publicado: (2022)

Induction of KSHV latency-associated nuclear antigen (LANA) by hypoxia and hypoxia-inducible factors (HIF)
por: Veeranna, Ravindra P, et al.
Publicado: (2012)

Correction: Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage
por: De Leo, Alessandra, et al.
Publicado: (2018)

NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency
por: Ma, Zhe, et al.
Publicado: (2017)

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4
por: Kumar, Ashish, et al.
Publicado: (2022)

KSHV (HHV8) vaccine: promises and potential pitfalls for a new anti-cancer vaccine
por: Casper, Corey, et al.
Publicado: (2022)

Diverse genotypes of Kaposi's sarcoma associated herpesvirus (KSHV) identified in infant blood infections in African childhood-KS and HIV/AIDS endemic region
por: Kasolo, FC, et al.
Publicado: (2007)

LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency
por: De Leo, Alessandra, et al.
Publicado: (2019)

iTIME.219: An Immortalized KSHV Infected Endothelial Cell Line Inducible by a KSHV-Specific Stimulus to Transition From Latency to Lytic Replication and Infectious Virus Release
por: Dollery, Stephen J., et al.
Publicado: (2021)

Presentation and Outcomes of Childhood Cancer Patients at Uganda Cancer Institute
por: Mutyaba, Innocent, et al.
Publicado: (2019)

K_s Reconstruction
por: Xie, Y
Publicado: (2003)

KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication
por: Johnston, Benjamin P., et al.
Publicado: (2019)

Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus
por: Dai, Lu, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rb34n5a2refvnj06hu2oa30inr