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Bayesian inference of protein conformational ensembles from limited structural data

Many proteins consist of folded domains connected by regions with higher flexibility. The details of the resulting conformational ensemble play a central role in controlling interactions between domains and with binding partners. Small-Angle Scattering (SAS) is well-suited to study the conformationa...

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Detalles Bibliográficos
Autores principales: Potrzebowski, Wojciech, Trewhella, Jill, Andre, Ingemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312354/
https://www.ncbi.nlm.nih.gov/pubmed/30557358
http://dx.doi.org/10.1371/journal.pcbi.1006641