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Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity

Glioblastoma is a malignant primary brain tumor with poor prognosis with a median survival of only 12–15 months. The high mortality rate of this disease is mainly due to the chemoresistance resulting from various reasons. Ubiquitin-specific protease 4 (USP4) has recently been found to be elevated in...

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Detalles Bibliográficos
Autores principales: Qin, Na, Han, Fengli, Li, Li, Ge, Yingwei, Lin, Wei, Wang, Jiang, Wu, Lin, Zhao, Gang, Deng, Yanchun, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312926/
https://www.ncbi.nlm.nih.gov/pubmed/30655854
http://dx.doi.org/10.3892/ol.2018.9654