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Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer

Intestinal bacteria are symbiotic microbiota within the human gut and are implicated in the occurrence and development of colorectal cancer (CRC). The current study investigated the changes in bacterial composition prior to and following surgery, as well as the differences in the bacterial community...

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Autores principales: Liu, Chen-Jian, Zhang, Yuan-Lian, Shang, Yun, Wu, Bian, Yang, En, Luo, Yi-Yong, Li, Xiao-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313076/
https://www.ncbi.nlm.nih.gov/pubmed/30655873
http://dx.doi.org/10.3892/ol.2018.9714
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author Liu, Chen-Jian
Zhang, Yuan-Lian
Shang, Yun
Wu, Bian
Yang, En
Luo, Yi-Yong
Li, Xiao-Ran
author_facet Liu, Chen-Jian
Zhang, Yuan-Lian
Shang, Yun
Wu, Bian
Yang, En
Luo, Yi-Yong
Li, Xiao-Ran
author_sort Liu, Chen-Jian
collection PubMed
description Intestinal bacteria are symbiotic microbiota within the human gut and are implicated in the occurrence and development of colorectal cancer (CRC). The current study investigated the changes in bacterial composition prior to and following surgery, as well as the differences in the bacterial community structure between cancer tissue and adjacent normal tissue. The diversity of the bacterial community and the composition of the bacteria were assessed. In addition, phylogenetic analysis and principle component analysis (PCA) were performed. The results revealed that cancer tissue and adjacent normal tissue exhibited similar bacterial compositions. However, a significant difference was identified in the composition of intestinal bacteria in stool samples collected from patients following surgery compared with stool samples collected prior to surgery. Each patient had their own unique intestinal bacterial community, likely due to a number of factors, including diet, genetic factors and health status. In addition, phylogenetic trees revealed that the most abundant operational taxonomic unit, 0001, was associated with Escherichia coli in all samples. Finally, PCA suggested that the bacterial community structure in all patient stools was similar following surgery. The current study provides information regarding the diversity of the intestinal bacterial community of patients with CRC and provides a basis for postoperative intestinal assessments.
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spelling pubmed-63130762019-01-17 Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer Liu, Chen-Jian Zhang, Yuan-Lian Shang, Yun Wu, Bian Yang, En Luo, Yi-Yong Li, Xiao-Ran Oncol Lett Articles Intestinal bacteria are symbiotic microbiota within the human gut and are implicated in the occurrence and development of colorectal cancer (CRC). The current study investigated the changes in bacterial composition prior to and following surgery, as well as the differences in the bacterial community structure between cancer tissue and adjacent normal tissue. The diversity of the bacterial community and the composition of the bacteria were assessed. In addition, phylogenetic analysis and principle component analysis (PCA) were performed. The results revealed that cancer tissue and adjacent normal tissue exhibited similar bacterial compositions. However, a significant difference was identified in the composition of intestinal bacteria in stool samples collected from patients following surgery compared with stool samples collected prior to surgery. Each patient had their own unique intestinal bacterial community, likely due to a number of factors, including diet, genetic factors and health status. In addition, phylogenetic trees revealed that the most abundant operational taxonomic unit, 0001, was associated with Escherichia coli in all samples. Finally, PCA suggested that the bacterial community structure in all patient stools was similar following surgery. The current study provides information regarding the diversity of the intestinal bacterial community of patients with CRC and provides a basis for postoperative intestinal assessments. D.A. Spandidos 2019-01 2018-11-15 /pmc/articles/PMC6313076/ /pubmed/30655873 http://dx.doi.org/10.3892/ol.2018.9714 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Liu, Chen-Jian
Zhang, Yuan-Lian
Shang, Yun
Wu, Bian
Yang, En
Luo, Yi-Yong
Li, Xiao-Ran
Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
title Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
title_full Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
title_fullStr Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
title_full_unstemmed Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
title_short Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
title_sort intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313076/
https://www.ncbi.nlm.nih.gov/pubmed/30655873
http://dx.doi.org/10.3892/ol.2018.9714
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