Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome characterized by a preserved ejection fraction but increased diastolic stiffness and abnormalities of filling. Although the prevalence of HFpEF is high and continues to rise, no effective therapies exist; however, the diabe...

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Detalles Bibliográficos
Autores principales: Slater, Rebecca E., Strom, Joshua G., Methawasin, Mei, Liss, Martin, Gotthardt, Michael, Sweitzer, Nancy, Granzier, Henk L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314384/
https://www.ncbi.nlm.nih.gov/pubmed/30567709
http://dx.doi.org/10.1085/jgp.201812259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314384/
https://www.ncbi.nlm.nih.gov/pubmed/30567709
http://dx.doi.org/10.1085/jgp.201812259

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