3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP

Despite extensive efforts spanning multiple decades, the development of highly effective Ca(2+) sensitizers for the heart remains an elusive goal. Existing Ca(2+) sensitizers have other targets in addition to cardiac troponin (cTn), which can lead to adverse side effects, such as hypotension or arrh...

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Detalles Bibliográficos
Autores principales: Tikunova, Svetlana B., Cuesta, Andres, Price, Morgan, Li, Monica X., Belevych, Natalya, Biesiadecki, Brandon J., Reiser, Peter J., Hwang, Peter M., Davis, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314390/
https://www.ncbi.nlm.nih.gov/pubmed/30442775
http://dx.doi.org/10.1085/jgp.201812131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314390/
https://www.ncbi.nlm.nih.gov/pubmed/30442775
http://dx.doi.org/10.1085/jgp.201812131

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