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3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP
Despite extensive efforts spanning multiple decades, the development of highly effective Ca(2+) sensitizers for the heart remains an elusive goal. Existing Ca(2+) sensitizers have other targets in addition to cardiac troponin (cTn), which can lead to adverse side effects, such as hypotension or arrh...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314390/ https://www.ncbi.nlm.nih.gov/pubmed/30442775 http://dx.doi.org/10.1085/jgp.201812131 |