Inducible down-regulation of MHC class I results in natural killer cell tolerance

Natural killer (NK) cells are innate lymphocytes that are thought to kill cells that down-regulate MHC class I (MHC-I) through “missing-self” recognition. NK cells from B2m(−/−) mice that lack surface MHC-I, however, are not autoreactive as predicted by the missing-self hypothesis. As a result, it i...

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Detalles Bibliográficos
Autores principales: Bern, Michael D., Parikh, Bijal A., Yang, Liping, Beckman, Diana L., Poursine-Laurent, Jennifer, Yokoyama, Wayne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314522/
https://www.ncbi.nlm.nih.gov/pubmed/30559128
http://dx.doi.org/10.1084/jem.20181076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314522/
https://www.ncbi.nlm.nih.gov/pubmed/30559128
http://dx.doi.org/10.1084/jem.20181076

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