Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4(+)CD8(+) thymocytes

Expression of Rag1 and Rag2 is tightly regulated in developing T cells to mediate TCR gene assembly. Here we have investigated the molecular mechanisms governing the assembly and disassembly of a transcriptionally active RAG locus chromatin hub in CD4(+)CD8(+) thymocytes. Rag1 and Rag2 gene expressi...

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Detalles Bibliográficos
Autores principales: Naik, Abani Kanta, Byrd, Aaron T., Lucander, Aaron C.K., Krangel, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314527/
https://www.ncbi.nlm.nih.gov/pubmed/30545902
http://dx.doi.org/10.1084/jem.20181402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314527/
https://www.ncbi.nlm.nih.gov/pubmed/30545902
http://dx.doi.org/10.1084/jem.20181402

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