Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enha...

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Detalles Bibliográficos
Autores principales: Chen, Zhiyang, Amro, Elias Moris, Becker, Friedrich, Hölzer, Martin, Rasa, Seyed Mohammad Mahdi, Njeru, Sospeter Ngoci, Han, Bing, Di Sanzo, Simone, Chen, Yulin, Tang, Duozhuang, Tao, Si, Haenold, Ronny, Groth, Marco, Romanov, Vasily S., Kirkpatrick, Joanna M., Kraus, Johann M., Kestler, Hans A., Marz, Manja, Ori, Alessandro, Neri, Francesco, Morita, Yohei, Rudolph, K. Lenhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314529/
https://www.ncbi.nlm.nih.gov/pubmed/30530755
http://dx.doi.org/10.1084/jem.20181505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314529/
https://www.ncbi.nlm.nih.gov/pubmed/30530755
http://dx.doi.org/10.1084/jem.20181505

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