RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on the mitochondrial outer membrane recruit autophagy cargo receptors in complexes with TBK1 protein kinase. While TBK1 is known to phosphoryl...

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Detalles Bibliográficos
Autores principales: Heo, J.-M., Ordureau, A., Swarup, S., Paulo, J. A., Shen, K., Sabatini, D. M., Harper, J. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314648/
https://www.ncbi.nlm.nih.gov/pubmed/30627666
http://dx.doi.org/10.1126/sciadv.aav0443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314648/
https://www.ncbi.nlm.nih.gov/pubmed/30627666
http://dx.doi.org/10.1126/sciadv.aav0443

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