The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR inhibition currently under clinical evaluatio...

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Detalles Bibliográficos
Autores principales: Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315032/
https://www.ncbi.nlm.nih.gov/pubmed/30602778
http://dx.doi.org/10.1038/s41467-018-07858-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315032/
https://www.ncbi.nlm.nih.gov/pubmed/30602778
http://dx.doi.org/10.1038/s41467-018-07858-8

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