CCR4-dependent reduction in the number and suppressor function of CD4(+)Foxp3(+) cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis

Chronic pulmonary inflammation marked predominantly by CD4(+)IFN-γ(+) cells is the hallmark of tuberculosis pathogenesis in immunocompetent adults, who are substantially affected by this disease. Moreover, CD4(+)Foxp3(+) cell-mediated suppression contributes to infection susceptibility. We addressed...

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Detalles Bibliográficos
Autores principales: Bertolini, Thais B., Piñeros, Annie R., Prado, Rafael Q., Gembre, Ana Flávia, Ramalho, Leandra N. Z., Alves-Filho, José Carlos, Bonato, Vânia L. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315058/
https://www.ncbi.nlm.nih.gov/pubmed/30584243
http://dx.doi.org/10.1038/s41419-018-1240-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315058/
https://www.ncbi.nlm.nih.gov/pubmed/30584243
http://dx.doi.org/10.1038/s41419-018-1240-3

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