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CCR4-dependent reduction in the number and suppressor function of CD4(+)Foxp3(+) cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis
Chronic pulmonary inflammation marked predominantly by CD4(+)IFN-γ(+) cells is the hallmark of tuberculosis pathogenesis in immunocompetent adults, who are substantially affected by this disease. Moreover, CD4(+)Foxp3(+) cell-mediated suppression contributes to infection susceptibility. We addressed...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315058/ https://www.ncbi.nlm.nih.gov/pubmed/30584243 http://dx.doi.org/10.1038/s41419-018-1240-3 |