Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

Abnormalities of the endolysosomal and autophagy systems are found in Alzheimer’s disease, but it is not clear whether defects in these systems are a cause or consequence of degenerative processes in the disease. In human neuronal models of monogenic Alzheimer’s disease, APP and PSEN1 mutations disr...

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Detalles Bibliográficos
Autores principales: Hung, Christy O.Y., Livesey, Frederick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315085/
https://www.ncbi.nlm.nih.gov/pubmed/30590039
http://dx.doi.org/10.1016/j.celrep.2018.11.095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315085/
https://www.ncbi.nlm.nih.gov/pubmed/30590039
http://dx.doi.org/10.1016/j.celrep.2018.11.095

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