Cargando…

Combining Optical Approaches with Human Inducible Pluripotent Stem Cells in G Protein-Coupled Receptor Drug Screening and Development

Drug discovery for G protein-coupled receptors (GPCRs) stands at an interesting juncture. Screening programs are slowly moving away from model heterologous cell systems such as human embryonic kidney (HEK) 293 cells to more relevant cellular, tissue and whole animal platforms. Investigators are now...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bourque, Kyla, Jones-Tabah, Jace, Mnasri, Nourhen, Martin, Ryan D., Hébert, Terence E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315445/ https://www.ncbi.nlm.nih.gov/pubmed/30567417 http://dx.doi.org/10.3390/biom8040180

Ejemplares similares

SAT-034 Photometry Based Measurement of G Protein-Coupled Receptor-Mediated Signalling
por: Jones-Tabah, Jace, et al.
Publicado: (2019)

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes
por: Bourque, Kyla, et al.
Publicado: (2023)

Distinct Conformational Dynamics of Three G Protein-Coupled Receptors Measured Using FlAsH-BRET Biosensors
por: Bourque, Kyla, et al.
Publicado: (2017)

The Signaling and Pharmacology of the Dopamine D1 Receptor
por: Jones-Tabah, Jace, et al.
Publicado: (2022)

SAT-033 Studying Cell-Context Specific Effects on the Function of the AT1R in iPSCs and Their Differentiated Derivatives
por: Bourque, Kyla, et al.
Publicado: (2019)

Dopamine D1 receptor signalling in dyskinetic Parkinsonian rats revealed by fiber photometry using FRET-based biosensors
por: Jones-Tabah, Jace, et al.
Publicado: (2020)

Measuring Single-Cell Calcium Dynamics Using a Myofilament-Localized Optical Biosensor in hiPSC-CMs Derived from DCM Patients
por: Hawey, Cara, et al.
Publicado: (2023)

G protein-coupled receptors in stem cell maintenance and somatic reprogramming to pluripotent or cancer stem cells
por: Choi, Hye Yeon, et al.
Publicado: (2015)

Optical modulation of excitation-contraction coupling in human-induced pluripotent stem cell-derived cardiomyocytes
por: Vurro, Vito, et al.
Publicado: (2023)

Drug screening platform using human induced pluripotent stem cell‐derived atrial cardiomyocytes and optical mapping
por: Gunawan, Marvin G., et al.
Publicado: (2020)

G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling
por: Dolatshad, Nazanin F., et al.
Publicado: (2015)

G1-phase progression in pluripotent stem cells
por: ter Huurne, Menno, et al.
Publicado: (2021)

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1
por: Srikanth, Manasa P., et al.
Publicado: (2021)

Design and Synthesis of Luminescent Lanthanide-Based Bimodal Nanoprobes for Dual Magnetic Resonance (MR) and Optical Imaging
por: Mnasri, Walid, et al.
Publicado: (2021)

Current status of drug screening and disease modelling in human pluripotent stem cells
por: Rajamohan, Divya, et al.
Publicado: (2013)

Induced Pluripotent Stem Cell-Based Drug Screening by Use of Artificial Intelligence
por: Kusumoto, Dai, et al.
Publicado: (2022)

Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells
por: Asenjo, Helena G., et al.
Publicado: (2020)

Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation
por: Wang, Yuming, et al.
Publicado: (2016)

G(i)-Coupled GPCR Signaling Controls the Formation and Organization of Human Pluripotent Colonies
por: Nakamura, Kenta, et al.
Publicado: (2009)

Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies
por: Rabesandratana, Oriane, et al.
Publicado: (2018)

Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening
por: Sharma, Arun, et al.
Publicado: (2013)

Phenotypic Drug Screening for Dysferlinopathy Using Patient‐Derived Induced Pluripotent Stem Cells
por: Kokubu, Yuko, et al.
Publicado: (2019)

Excitation–contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes
por: Kane, Christopher, et al.
Publicado: (2015)

Glycolysis Combined with Core Pluripotency Factors to Promote the Formation of Chicken Induced Pluripotent Stem Cells
por: Yuan, Xia, et al.
Publicado: (2021)

Regulation of CpG methylation by Dnmt and Tet in pluripotent stem cells
por: HORII, Takuro, et al.
Publicado: (2016)

Pluripotency of induced pluripotent stem cells
por: Kang, Lan, et al.
Publicado: (2012)

Pluripotency of Induced Pluripotent Stem Cells
por: Feng, Chunjing, et al.
Publicado: (2013)

Allosteric Optical Control of a Class B G‐Protein‐Coupled Receptor
por: Broichhagen, Johannes, et al.
Publicado: (2016)

Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells
por: Djemai, Mohammed, et al.
Publicado: (2023)

Disease modeling and drug screening for neurological diseases using human induced pluripotent stem cells
por: Xu, Xiao-hong, et al.
Publicado: (2013)

Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis?
por: Martin, Ulrich
Publicado: (2015)

Human Induced Pluripotent Stem Cells as a Screening Platform for Drug-Induced Vascular Toxicity
por: Tu, Chengyi, et al.
Publicado: (2021)

Induced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency
por: Kouchaki, Reza, et al.
Publicado: (2020)

Differential Coupling of Self-Renewal Signaling Pathways in Murine Induced Pluripotent Stem Cells
por: Orlando, Luca, et al.
Publicado: (2012)

Drug Development and the Use of Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Disease Modeling and Drug Toxicity Screening
por: Ovics, Paz, et al.
Publicado: (2020)

Stem cells and pluripotency: emerging themes and tools
por: Camargo, Fernando D., et al.
Publicado: (2012)

Endothelial Differentiation G Protein‐Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency
por: Neganova, Irina, et al.
Publicado: (2019)

Induced pluripotent stem cell technology for disease modeling and drug screening with emphasis on lysosomal storage diseases
por: Huang, Hsiang-Po, et al.
Publicado: (2012)

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation
por: Blondel, S, et al.
Publicado: (2016)

Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19
por: Nolasco, Patricia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v2gevpms66e82e76vbh4f0u2j1