Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models

α-Conotoxins from Conus snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). α-Conotoxin RgIA and αO-conotoxin GeXIVA, blocking neuronal α9α10 nAChR, are potential analgesics. Typically, α-conotoxins bind to the orthosteric sites for agonists/competiti...

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Detalles Bibliográficos
Autores principales: Kryukova, Elena V., Ivanov, Igor A., Lebedev, Dmitry S., Spirova, Ekaterina N., Egorova, Natalia S., Zouridakis, Marios, Kasheverov, Igor E., Tzartos, Socrates J., Tsetlin, Victor I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315749/
https://www.ncbi.nlm.nih.gov/pubmed/30469507
http://dx.doi.org/10.3390/md16120460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315749/
https://www.ncbi.nlm.nih.gov/pubmed/30469507
http://dx.doi.org/10.3390/md16120460

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