Oxidation of 5-methylaminomethyl uridine (mnm(5)U) by Oxone Leads to Aldonitrone Derivatives

Oxidative RNA damage is linked to cell dysfunction and diseases. The present work focuses on the in vitro oxidation of 5-methylaminomethyl uridine (mnm(5)U), which belongs to the numerous post-transcriptional modifications that are found in tRNA. The reaction of oxone with mnm(5)U in water at pH 7.5...

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Detalles Bibliográficos
Autores principales: Zhou, Qishun, Vu Ngoc, Bao Tram, Leszczynska, Grazyna, Stigliani, Jean-Luc, Pratviel, Geneviève
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315764/
https://www.ncbi.nlm.nih.gov/pubmed/30441840
http://dx.doi.org/10.3390/biom8040145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315764/
https://www.ncbi.nlm.nih.gov/pubmed/30441840
http://dx.doi.org/10.3390/biom8040145

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