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Oxidation of 5-methylaminomethyl uridine (mnm(5)U) by Oxone Leads to Aldonitrone Derivatives

Oxidative RNA damage is linked to cell dysfunction and diseases. The present work focuses on the in vitro oxidation of 5-methylaminomethyl uridine (mnm(5)U), which belongs to the numerous post-transcriptional modifications that are found in tRNA. The reaction of oxone with mnm(5)U in water at pH 7.5...

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Detalles Bibliográficos
Autores principales:	Zhou, Qishun, Vu Ngoc, Bao Tram, Leszczynska, Grazyna, Stigliani, Jean-Luc, Pratviel, Geneviève
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315764/ https://www.ncbi.nlm.nih.gov/pubmed/30441840 http://dx.doi.org/10.3390/biom8040145

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