Acute Toxicity of the Recombinant and Native Phα1β Toxin: New Analgesic from Phoneutria nigriventer Spider Venom

Phα1β, a purified peptide from the venom of the spider Phoneutria nigriventer, and its recombinant form CTK 01512-2 are voltage-dependent calcium channel (Ca(V)) blockers of types N, R, P/Q, and L with a preference for type N. These peptides show analgesic action in different pain models in rats. Th...

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Detalles Bibliográficos
Autores principales: Dallegrave, Eliane, Taschetto, Eliane, Bainy Leal, Mirna, Techera Antunes, Flavia Tasmim, Gomez, Marcus Vinicius, Hubner de Souza, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315920/
https://www.ncbi.nlm.nih.gov/pubmed/30545036
http://dx.doi.org/10.3390/toxins10120531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315920/
https://www.ncbi.nlm.nih.gov/pubmed/30545036
http://dx.doi.org/10.3390/toxins10120531

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