Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex and poorly understood. Here, we describe for the fir...

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Detalles Bibliográficos
Autores principales: Englinger, Bernhard, Kallus, Sebastian, Senkiv, Julia, Laemmerer, Anna, Moser, Patrick, Gabler, Lisa, Groza, Diana, Kowol, Christian R., Heffeter, Petra, Grusch, Michael, Berger, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315953/
https://www.ncbi.nlm.nih.gov/pubmed/30544798
http://dx.doi.org/10.3390/cells7120259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315953/
https://www.ncbi.nlm.nih.gov/pubmed/30544798
http://dx.doi.org/10.3390/cells7120259

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