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Design of Linear and Cyclic Mutant Analogues of Dirucotide Peptide (MBP(82–98)) against Multiple Sclerosis: Conformational and Binding Studies to MHC Class II
Background: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. MS is a T cell-mediated disease characterized by the proliferation, infiltration, and attack of the myelin sheath by immune cells. Previous studies have shown that cyclization provides molecules with strict...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316436/ https://www.ncbi.nlm.nih.gov/pubmed/30518150 http://dx.doi.org/10.3390/brainsci8120213 |