A Gemini Cationic Lipid with Histidine Residues as a Novel Lipid-Based Gene Nanocarrier: A Biophysical and Biochemical Study

This work reports the synthesis of a novel gemini cationic lipid that incorporates two histidine-type head groups (C(3)(C(16)His)(2)). Mixed with a helper lipid 1,2-dioleoyl-sn-glycero-3-phosphatidyl ethanol amine (DOPE), it was used to transfect three different types of plasmid DNA: one encoding th...

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Detalles Bibliográficos
Autores principales: Martínez-Negro, María, Blanco-Fernández, Laura, Tentori, Paolo M., Pérez, Lourdes, Pinazo, Aurora, Tros de Ilarduya, Conchita, Aicart, Emilio, Junquera, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316511/
https://www.ncbi.nlm.nih.gov/pubmed/30558369
http://dx.doi.org/10.3390/nano8121061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316511/
https://www.ncbi.nlm.nih.gov/pubmed/30558369
http://dx.doi.org/10.3390/nano8121061

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