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Differential Expression of HOX Genes in Mesenchymal Stem Cells from Osteoarthritic Patients Is Independent of Their Promoter Methylation

Skeletogenesis, remodeling, and maintenance in adult tissues are regulated by sequential activation of genes coding for specific transcription factors. The conserved Homeobox genes (HOX, in humans) are involved in several skeletal pathologies. Osteoarthritis (OA) is characterized by homeostatic alte...

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Detalles Bibliográficos
Autores principales: Mucientes, Arkaitz, Herranz, Eva, Moro, Enrique, Lajas, Cristina, Candelas, Gloria, Fernández-Gutiérrez, Benjamín, Lamas, José Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316585/
https://www.ncbi.nlm.nih.gov/pubmed/30563049
http://dx.doi.org/10.3390/cells7120244