The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation

Mammalian DNMT1 is mainly responsible for maintenance DNA methylation that is critical in maintaining stem cell pluripotency and controlling lineage specification during early embryonic development. A number of studies have demonstrated that DNMT1 is an auto-inhibited enzyme and its enzymatic activi...

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Detalles Bibliográficos
Autores principales: Xie, Si, Qian, Chengmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316679/
https://www.ncbi.nlm.nih.gov/pubmed/30513966
http://dx.doi.org/10.3390/genes9120600
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author Xie, Si
Qian, Chengmin
author_facet Xie, Si
Qian, Chengmin
author_sort Xie, Si
collection PubMed
description Mammalian DNMT1 is mainly responsible for maintenance DNA methylation that is critical in maintaining stem cell pluripotency and controlling lineage specification during early embryonic development. A number of studies have demonstrated that DNMT1 is an auto-inhibited enzyme and its enzymatic activity is allosterically regulated by a number of interacting partners. UHRF1 has previously been reported to regulate DNMT1 in multiple ways, including control of substrate specificity and the proper genome targeting. In this review, we discuss the recent advances in our understanding of the regulation of DNMT1 enzymatic activity by UHRF1 and highlight a number of unresolved questions.
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spelling pubmed-63166792019-01-09 The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation Xie, Si Qian, Chengmin Genes (Basel) Review Mammalian DNMT1 is mainly responsible for maintenance DNA methylation that is critical in maintaining stem cell pluripotency and controlling lineage specification during early embryonic development. A number of studies have demonstrated that DNMT1 is an auto-inhibited enzyme and its enzymatic activity is allosterically regulated by a number of interacting partners. UHRF1 has previously been reported to regulate DNMT1 in multiple ways, including control of substrate specificity and the proper genome targeting. In this review, we discuss the recent advances in our understanding of the regulation of DNMT1 enzymatic activity by UHRF1 and highlight a number of unresolved questions. MDPI 2018-12-03 /pmc/articles/PMC6316679/ /pubmed/30513966 http://dx.doi.org/10.3390/genes9120600 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xie, Si
Qian, Chengmin
The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
title The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
title_full The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
title_fullStr The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
title_full_unstemmed The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
title_short The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
title_sort growing complexity of uhrf1-mediated maintenance dna methylation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316679/
https://www.ncbi.nlm.nih.gov/pubmed/30513966
http://dx.doi.org/10.3390/genes9120600
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