Synthesis and Initial In Vivo Evaluation of [(11)C]AZ683—A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R)

Positron emission tomography (PET) imaging of Colony Stimulating Factor 1 Receptor (CSF1R) is a new strategy for quantifying both neuroinflammation and inflammation in the periphery since CSF1R is expressed on microglia and macrophages. AZ683 has high affinity for CSF1R (K(i) = 8 nM; IC(50) = 6 nM)...

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Detalles Bibliográficos
Autores principales: Tanzey, Sean S., Shao, Xia, Stauff, Jenelle, Arteaga, Janna, Sherman, Phillip, Scott, Peter J. H., Mossine, Andrew V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316681/
https://www.ncbi.nlm.nih.gov/pubmed/30551596
http://dx.doi.org/10.3390/ph11040136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316681/
https://www.ncbi.nlm.nih.gov/pubmed/30551596
http://dx.doi.org/10.3390/ph11040136

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